Endocrine Abstracts

The transcription factor HIF-1α regulates hypoxia-mediated gene expression which promotes tumour growth, metastasis and desensitisation to chemo-and radiotherapy. HIF-1 is functional in a range of thyroid-carcinoma cells and is regulated by hypoxia and the PI3K and MAPK-signalling pathways.We aimed to determine if HIF-1 and PI3K were important in the development of a metastatic phenotype and play a role in desensitisation to radiotherapy in thyroid ...

The anti-inflammatory protein, annexin 1 (ANXA1) acts via a formyl peptide receptor (FPR), possibly FPR2, in the neuroendocrine system to mediate feedback effects of glucocorticoids and thereby modulate the HPA responses to immune insults. Here, we explored further the role of ANXA1 and the FPR family in mediating the HPA responses to endotoxin (LPS), focusing on the adrenal cortex.Adult male mice treated with LPS (500 μg/kg, i.p.) showed time-depen...

Aim: To evaluate the frequency and morpho-histological characteristics of the colonic polyps (CP) in acromegaly patients (pts).Materials and methods: We studied 53 pts (50 female, 3 men) aged 23–76 (median – 47) with active acromegaly. The mean disease duration was 10.7±4.3 years. Somatotropinoma was diagnosed in 51 pts and somatoprolactinoma in two. The activity of acromegal? was confirmed on the base of the clinical and hormonal data. Ba...

Aim: To estimate efficiency of long acting somatostatin analog (Oktreotid-Depot, Ltd ‘FarmSyntez’, Russia) in acromegaly treatment.Material and methods: Twenty-five patients with the confirmed acromegaly diagnosis, active phase, receiving Oktreotid-Depot therapy within 6–12 months in a single dose of 20–40 mg/month. Every three months dynamics of clinical signs, basal IGF-1 and GH levels and pituitary adenoma size were analyzed.<p...

Introduction: Type 1 diabetes is one the most common chronic diseases found in children and youngsters.Objectives: Characterization of a sample of young type 1 diabetic patients, treated with multiple daily injections of insulin.Patients and methods: Analysis of patients files with ages between 11 and 26 years observed on diabetology consultation during the first semester of 2008, with diagnosis of diabetes for at least 6 months. P...

Selective enhancement of glucocorticoid action in adipose tissue has been shown to induce characteristic features of the metabolic syndrome. Adipocyte-derived factors provide a link between altered adipose tissue mass and function and cardiovascular disease. However, key mechanisms controlling these pathophysiological alterations in adipose tissue are poorly understood. Recently, both, the glucocorticoid (GR) and the mineralocorticoid receptor (MR), have been shown to mediate ...

Background: Primary squamous cell carcinomas of the thyroid are uncommon entities with less than 100 cases described in the literature.Case report: We report on the imaging findings in a rare case of primary squamous cell carcinoma of the thyroid that was found to be the primary tumour of humerus and cervical lymph node metastases. Other sources of squamous cell cancer were ruled out by a careful search, including whole body computed tomography (CT), pos...

There is growing evidence that pituitary failure is a common complication of traumatic brain injury. However, prevalence of hypopituitarism following traumatic brain injury varies between 25 and 69% in the literature. Moreover, the pattern of involved hypothalamic/pituitary axes differs considerably in the published trials. This might be due to small and inhomogeneous series of patients and different test methods in previous studies. The aim of our study was therefore to inves...

Introduction: In Graves’ hyperthyroidism with long-term antithyroid drugs (ATD) treatment, remission is often umpredictable. However variables at diagnosis or at the end of the ATD regimen are associated with a highest likelihood of recurrence and could be used to decide an ablative treatment.Objective: To identify variables before and at the end of a long-term treatment with ATD (>6 months) associated with higher rates of relapse during a follo...

Context: HIF-1α is frequently upregulated in many tumour types and has been shown to be critical for radio- and chemosensitivity in pre-clinical studies. However the regulation and function of HIF-1α is unknown in thyroid carcinomas.Objectives: Here, we evaluated basal expression and regulation of HIF-1α and target genes in primary thyroid carcinomas and in thyroid cancer cell lines (NPA, FTC-133, ARO).Design and out...